Unlike the 27-inch iMac, the iMac Pro does not have a memory access port, though memory can be upgraded by Apple Stores and authorized service providers. The processor, memory, and storage are not soldered and can be removed. Unlike the white accessories that come with the iMac, the iMac Pro came with a black Magic Keyboard with a numeric keypad, and a black Magic Mouse or Magic Trackpad. The iMac Pro's chassis is carried over from the 27-inch iMac introduced in 2012 but is only available in a darker 'space gray' finish. An indirect successor, the Mac Studio, was released on March 18, 2022, alongside the Apple Studio Display. It was delisted from Apple's website and online store on March 19, 2021.

On March 5, 2021, Apple discontinued the iMac Pro and said it would continue selling it while supplies last.

On August 4, 2020, Apple discontinued the 8-core model and made the 10-core model, previously an upgrade option, the base model. On March 19, 2019, options for 256 GB of memory and a Vega 64X GPU were added. It includes a custom Apple T2 chip to store encrypted keys, and a custom version of macOS that allows the user to lock down the booting process. It includes an 8-, 10-, 14-, or 18-core Intel Xeon processor, 5K display, AMD Vega graphics, ECC memory, and 10 Gigabit Ethernet. Apple billed it as 'the most powerful Mac ever made'. The iMac Pro was introduced at WWDC on Jand was released in December 2017. As part of the announcement, a new monitor and Mac Pro were announced, but would not arrive that year instead, Apple referenced new iMacs to fill the gap. In April 2017, Apple convened a roundtable of journalists and executives to restate their commitment to professional Macs. The machine languished for years without any updates, and Apple later admitted that its small design and focus on dual graphics-processing unit had been a mistake. In 2013, Apple replaced its tower Mac Pro workstation with a radically-redesigned model.

2017 mac pro tower